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home >> research >> tobprac presentations
TobPRAC Presentations
Presentation summary: An evaluation of new tobacco products, this presentation reviews the term harm reduction and provides evidence that harm reduction is feasible. Additionally it describes methods to study PREPS (Potential Reduced Exposure Products) and examples of this product type. It reviews biomarker studies and introduces TobPRAC (Tobacco Product Assessment Consortium), the in-depth tobacco study funded by National Cancer Institute with the objective of providing a sound science base for tobacco regulation tobacco harm reduction products.
Authors: Dr. Peter G. Shields, MD, TobPRAC Principal Investigator
Laboratory location: Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC.
Presentation Location and date: National Cancer Institute, Bethesda, MD, Nov. 11, 2008
Presentation summary: This presentation reviews the term harm reduction and provides evidence that harm reduction is feasible. It establishes the science base to support the application for claims, such as weight of evidence review and risk assessment. It describes SNUS smokeless tobacco and the statistics collected to date in Sweden regarding use and unanswered questions about SNUS and harm reduction.
Authors: Dr. Peter G. Shields, MD, TobPRAC Principal Investigator
Laboratory location: Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC.
Presentation Location and date: Annual Meeting of the Association of Health Care Journalists - March 30, 2008
Presentation summary: The goals of these microarray studies are to: * Identify new genes and pathways that are affected by cigarette smoke in general, and nicotine in particular * To identify specific genes or pattern of genes that reflect smoke and nicotine exposure as a future biomarker of cellular effect * To establish a screening method for broad changes in smoke constituent exposure or for unanticipated constituent changes.
Authors: Dr. Peter G. Shields, MD, TobPRAC Principal Investigator
Laboratory location: Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC. The Sixth Annual American Association for Cancer Research (AACR) Conference on Frontiers in Cancer Prevention Research; Philadelphia, Dec 5-8, 2007.
Presentation Location and date: The Sixth Annual American Association for Cancer Research (AACR) Conference on Frontiers in Cancer Prevention Research; Philadelphia, Dec 5-8, 2007.
Presentation summary: Most cancer is caused by lifestyle factors involving carcinogen exposure and consequent DNA adduct formation. * Multiple mutations in cancer cells result from miscoding of un-repaired DNA adducts. * Dietary, environmental, tobacco-derived, occupational and endogenous carcinogens have been well characterized. * Carcinogen derived biomarkers can lead to mechanistic understanding and approaches to prevention, particularly when integrated into genotyping studies.
Authors: Stephen Hecht, PhD, TobPRAC Site-Principal Investigator, University of Minnesota Cancer Center, Minneapolis, MN
Laboratory location: University of Minnesota Cancer Center, Minneapolis, MN
Date published (or written): The Sixth Annual American Association for Cancer Research (AACR) Conference on Frontiers in Cancer Prevention Research; Philadelphia, Dec 5-8, 2007.
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